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How Does PEP Treatment Fight Off HIV and Keep You Safe?

Updated: Nov 22, 2023

Home > Blog > How Does PEP Treatment Fight Off HIV and Keep You Safe?

PEP Treatment

Staying updated on the latest developments in healthcare is crucial, especially in the ever-evolving field of disease prevention and management. Post-Exposure Prophylaxis (PEP) medications have emerged as a significant advancement in the battle against Human Immunodeficiency Virus (HIV). These medications can halt the progression of HIV infection once a person has been exposed to the virus. It's imperative to initiate PEP treatment as soon as possible, ideally within 72 hours of exposure. In this blog, we will explore how Post-Exposure Prophylaxis HIV treatment can effectively combat the virus and contribute to your overall safety and well-being.

What is PEP?

Human Immunodeficiency Virus (HIV) has the potential to infect and cause harm to the body. Therefore, Post-Exposure Prophylaxis (PEP) consists of a brief course of medication offered in cases of potential exposure. To achieve its maximum effectiveness, PEP should be administered within 72 hours of the initial exposure. However, it is important to note that PEP is not recommended for individuals with recurring exposure to HIV and should only be considered as an emergency measure.

Who Should Consider for PEP?

PEP should be considered by anyone who suspects potential exposure to HIV. Common reasons for needing PEP medication include:

  • Engaging in anal sex without a condom or when a condom breaks during intercourse with an HIV-positive or potentially infected partner.

  • Sharing syringes or needles with an individual who may or may not have HIV.

How to Know If You Need PEP?

If you uncertain about your HIV status but have been exposed to the virus within the past 72 hours, Post-Exposure Prophylaxis (PEP) can be a valuable option. Situations that may lead to exposure include sharing needles for drug injection or experiencing a condom break during intercourse with an HIV-positive partner.

It is strongly recommended to consult your healthcare provider or visit a family and sexual health clinic promptly if any of these circumstances apply to you. Medical professionals can assess your situation and prescribe the appropriate PEP medications. If PEP is prescribed, it is crucial to complete the full 28-day course of medication and follow up with clinic visits for HIV and other relevant tests to rule out any potential infections or complications.

What to Expect if You Take PEP Medication?

After discussing PEP and its timing, let's delve into what to expect both before and after undergoing PEP treatment.

Before Starting PEP Treatment

A medical evaluation is conducted by the doctor to determine the risk of HIV exposure before prescribing PEP. Higher chances of HIV transmission are associated with the following scenarios:

  • Direct contact occurred between body fluids that may contain HIV (e.g., from an HIV-positive or unknown HIV status individual) and the bloodstream or mucous membranes.

  • An individual is not currently adhering to their doctor's prescribed PrEP regimen as a preventive measure against HIV.

Additionally, a healthcare provider will typically administer a rapid HIV test before prescribing PEP. PEP is not recommended for individuals who are already HIV-positive, and it's estimated that 1 in 7 HIV-positive individuals are unaware of their infection.

After PEP Medication:

After completing a PEP course, it is essential to undergo an HIV test to assess the effectiveness of the treatment.

Consider getting tested immediately after PEP treatment completion and again three months after the initial exposure. For those who may have contracted hepatitis C during a potential HIV exposure, additional HIV testing is necessary six months after the encounter.

What Are the Side Effects of PEP Treatment?

PEP is generally safe, but some patients may experience side effects, including nausea due to the HIV medications used in PEP. Most of the time, these side effects are manageable and not harmful. If you encounter any side effects while taking PEP that are bothersome or persistent, it's essential to discuss them with your healthcare provider.

Furthermore, individuals receiving PEP medications may experience potential drug interactions with other medications they are taking. Therefore, it's crucial to inform your doctor about any other medications you may be using.

Does PEP Treatment Work?

PEP can be effective in preventing HIV infection when taken correctly, although it is not guaranteed to be 100% effective. The effectiveness of PEP is greatly influenced by how quickly it is initiated after a potential HIV exposure.

In addition to PEP, it is essential to incorporate other HIV prevention strategies, such as consistent and correct condom usage during every sexual encounter, and the strict use of clean, sterile needles and equipment when injecting drugs. Combining these prevention methods enhances overall protection against HIV transmission.


Post-Exposure Prophylaxis HIV medication stands as a potent tool in the ongoing battle against HIV. Its proper and timely use can significantly reduce the risk of HIV infection following potential exposure to the virus. At Little Cross Family Clinic Pte Ltd, we prioritize your health and safety, offering information on HIV prevention and treatment while providing guidance and support.

Don't hesitate to reach out to our healthcare professionals if you suspect HIV exposure or have questions about PEP medications. We are committed to assisting you at every stage, ensuring your well-being and peace of mind. Taking early action is paramount in preventing HIV infection. Stay informed and protected, and allow us to be your partners in healthcare.


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